توضیحات
Practical Application of Supercritical Fluid Chromatography for Pharmaceutical Research and Development provides a valuable go-to reference for many difficult-to-solve challenges using pertinent chromatographic theory, first-hand case studies, and examples provided from academic and industry experts. This text also enables professors teaching an analytical instrumental course to introduce and instruct students about one of the most sustainable and powerful separation methods currently available. While the text has broad applicability across industrial sectors, it focuses primarily on application in the pharmaceutical industry. The book is designed to allow readers to align current HPLC/UHPLC capabilities with SFC as an orthogonal tool for project specific methods in the pharmaceutical industry. It highlights where SFC falls on the spectrum of useful chromatographic tools for routine and challenging separative methods.
Experienced HPLC users who are interested in developing knowledge in orthogonal separation techniques, as well as newcomers to the field of separation science, will find this text particularly useful. Chapters address where SFC may fit the analytical needs of the pharmaceutical industry and alert the readers as to where the technique will not fit. Readers will gain an understanding of how and where SFC may be applied and adapted more routinely across the pharmaceutical industry as a green way of undertaking separation opportunities and challenges. Areas within the pharmaceutical industry include early drug discovery, process chemistry, and late stage development and manufacturing.
Describes approaches to SFC column and mobile phase selection for method development for both analytical and preparative tasks.
Gives practical examples of how analytical SFC enables the monitoring of synthetic reactions including unstable intermediates, chiral and achiral polar reactants and products across small and large modalities.
Provides need-focused case studies for pharmaceutical analysts, process chemists, and contract chemistry facilities that can benefit from monitoring or purifying polar intermediates, mutagenic impurities, nitrosamines and other reaction by-products including excipients and metabolites.
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ترجمه ماشینی :
کاربرد عملی کروماتوگرافی سیال فوق بحرانی برای تحقیق و توسعه دارویی، با استفاده از تئوری کروماتوگرافی مربوطه، مطالعات موردی دست اول، و مثالهای ارائه شده از کارشناسان دانشگاهی و صنعتی، مرجع ارزشمندی برای بسیاری از چالشهای غیرقابل حل است. این متن همچنین اساتیدی را قادر میسازد که یک دوره ابزار تحلیلی را تدریس کنند تا یکی از پایدارترین و قویترین روشهای جداسازی موجو
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