توضیحات
This book details the role played by analytical chemistry in fostering clinical research. Readers will discover how a broad range of analytical techniques support all phases of clinical research, from early stages to the implementation of practical applications. Moreover, the contributing authors’ careful step-by-step guidance enables readers to better understand standardized techniques and steer clear of everyday problems that can arise in the lab.
Analytical Techniques for Clinical Chemistry opens with an overview of the legal and regulatory framework governing clinical lab analysis. Next, it details the latest progress in instrumentation and applications in such fields as biomonitoring, diagnostics, food quality, biomarkers, pharmaceuticals, and forensics. Comprised of twenty-five chapters divided into three sections exploring Fundamentals, Selected Applications, and Future Trends, the book covers such critical topics as:
- Uncertainty in clinical chemistry measurements
- Metal toxicology in clinical, forensic, and chemical pathology
- Role of analytical chemistry in the safety of drug therapy
- Atomic spectrometric techniques for the analysis of clinical samples
- Biosensors for drug analysis
- Use of X-ray techniques in medical research
Each chapter is written by one or more leading pioneers and experts in analytical chemistry. Contributions are based on a thorough review and analysis of the current literature as well as the authors’ own firsthand experiences in the lab. References at the end of each chapter serve as a gateway to the literature, enabling readers to explore individual topics in greater depth.
Presenting the latest achievements and challenges in the field, Analytical Techniques for Clinical Chemistry sets the foundation for future advances in laboratory research techniques.
Content:
Chapter 1 Good Clinical Practice Principles: Legal Background and Applicability (pages 127): Umberto Filibeck, Angela Del Vecchio and Fabrizio Galliccia
Chapter 2 Clinical Chemistry and the Quest for Quality (pages 2958): Sergio Caroli
Chapter 3 Uncertainty in Clinical Chemistry Measurements Including Preanalytical Variables (pages 5996): Marit Sverresdotter Sylte, Tore Wentzel?Larsen and Bjorn J. Bolann
Chapter 4 The Role and Significance of Reference Values in the Identification and Evaluation of Trace Elements from Diet (pages 97125): Pietro Apostoli and Maria Cristina Ricossa
Chapter 5 Sample Collection, Storage, and Pretreatment in Clinical Chemistry (pages 127137): Andrew Taylor
Chapter 6 Metal Toxicology in Clinical, Forensic, and Chemical Pathology (pages 139156): Jose A. Centeno, Todor I. Todorov, Gijsbert B. van der Voet and Florabel G. Mullick
Chapter 7 Elemental Speciation in Clinical Sciences (pages 157177): Douglas M. Templeton
Chapter 8 The Role of Analytical Chemistry in the Safety of Drug Therapy (pages 179243): Sandor Gorog
Chapter 9 Analytical Techniques and Quality Control of Pharmaceuticals (pages 245255): Fedele Manna, Francesca Rossi and Rossella Fioravanti
Chapter 10 Detection of Drugs in Biological Fluids for Antidoping Control (pages 257268): Sabina Strano and Marcello Chiarotti
Chapter 11 The Applicability of Plasma?Based Techniques to Biological Monitoring (pages 269317): Ilse Steffan and Goran Vujicic
Chapter 12 Atomic Spectrometric Techniques for the Analysis of Clinical Samples (pages 319366): Pilar Bermejo Barrera, Antonio Moreda Pineiro and Maria del Carmen Barciela Alonso
Chapter 13 Applications of ICP?MS in Human Biomonitoring Studies (pages 367395): Peter Heitland and Helmut D. Koster
Chapter 14 Molybdenum in Biological Samples and Clinical Significance of Serum Molybdenum (pages 397408): Munehiro Yoshida
Chapter 15 Application of Organometallic Speciation in Clinical Studies (pages 409453): Bin He, Chungang Yuan, Jing Sun and Guibin Jiang
Chapter 16 Biosensors for Drug Analysis (pages 455478): Daniela Deriu and Franco Mazzei
Chapter 17 Bioimaging of Metals and Proteomic Studies of Clinical Samples by Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA?ICP?MS) (pages 479505): Sabine Becker and Susanne Becker
Chapter 18 Applications of LC?MS/MS in Clinical Laboratory Diagnostics (pages 507534): Uta Ceglarek, Georg Martin Fiedler and Joachim Thiery
Chapter 19 Metabolomics Using UPLC/HPLC?Tandem Mass Spectrometry in Diagnosis and Research of Inherited Metabolic Diseases (pages 535553): Willem Kulik and Andre B. P. van Kuilenburg
Chapter 20 Biomarkers of Oxidative Stress in Plasma and Urine (pages 555594): Papasani V. Subbaiah
Chapter 21 The Use of X?Ray Techniques in Medical Research (pages 595623): Imre Szaloki, Gyula Zaray and Norbert Szoboszlai
Chapter 22 A New Tool Based on the Use of Stable Isotopes and Isotope Pattern Deconvolution (IPD)?ICP?MS for Nutritional and Clinical Studies (pages 625649): Hector Gonzalez Iglesias, Maria Luisa Fernandez?Sanchez and Alfredo Sanz?Medel
Chapter 23 Breath Analysis: Analytical Methodologies and Clinical Applications (pages 651689): Alessio Ceccarini, Fabio Di Francesco, Roger Fuoco, Silvia Ghimenti, Massimo Onor, Sara Tabucchi and Maria Giovanna Trivella
Chapter 24 Proteo?Metabolomic Strategies in the Future of Drug Development (pages 691774): Uwe Christians, Volker Schmitz, Jost Klawitter and Jelena Klawitter
Chapter 25 Basics in Laboratory Medicine: Past, Present, and Future (pages 775785): Lorand A. Debreczeni, Anna Kovacsay and Sandor Nagy
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ترجمه ماشینی :
این کتاب به جزئیات نقش شیمی تحلیلی در تقویت تحقیقات بالینی می پردازد. خوانندگان متوجه خواهند شد که چگونه طیف گسترده ای از تکنیک های تحلیلی از تمام مراحل تحقیقات بالینی، از مراحل اولیه تا اجرای کاربردهای عملی پشتیبانی می کند. علاوه بر این، راهنمای گام به گام دقیق نویسندگان مشارکت کننده، خوانندگان را قادر می سازد تا تکنیک های استاندارد شده را بهتر درک کنند و از مشکلات روزمره ای که ممکن است در آزمایشگاه ایجاد می شود، دوری کنند.
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