دانلود کتاب Neurodegeneration: Exploring Commonalities Across Diseases: Workshop Summary – تولید عصبی: بررسی مشترکات در سراسر بیماری ها: خلاصه کارگاه

توضیحات

Neurodegeneration: Exploring Commonalities Across Diseases is the summary of a workshop hosted by the Institute of Medicine\’s (IOM\’s) Forum on Neuroscience and Nervous System Disorders in Spring 2012 to explore commonalities across neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD). Participants from academia; pharmaceutical and biotechnology industries; government agencies such as the National Institutes of Health and the U.S. Department of Veterans Affairs (VA); patient advocacy groups; and private foundations presented and identified potential opportunities for collaboration across the respective research and development communities. This report identifies and discusses commonalities related to genetic and cellular mechanisms, identifies areas of fundamental science needed to facilitate therapeutics development, and explores areas of potential collaboration among the respective research communities.

Neurodegenerative diseases, such as Alzheimer\’s disease, Parkinson\’s disease, ALS, and FTD, are becoming increasingly prevalent in the United States due to an aging population. Implications are grave for quality of life and health care costs. Research on neurodegenerative diseases has expanded greatly over the past four decades. Nevertheless, fundamental questions remain about the biology of these diseases, and further insights into the mechanisms of these diseases would help to inform the development of effective means to prevent and to efficiently treat them. Recent findings have revealed certain commonalities in genetic and cellular mechanisms across neurodegenerative diseases. These findings suggest that it might be valuable – at least in some cases – to change the traditional way of studying these diseases by no longer seeing each as an independent entity, but rather as clinical variants of common cellular and molecular biological defects. This approach could help enhance basic scientific understanding of neurodegenerative disease, and could help with the development of biomarkers and new therapeutics.

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ترجمه ماشینی :

تولید عصبی: بررسی مشترکات در سراسر بیماری ها ، خلاصه ای از کارگاه آموزشی است که توسط موسسه پزشکی \ (IOM) در مورد علوم اعصاب و اختلالات سیستم عصبی در بهار 2012 به منظور کشف مشترکات در سراسر سال 2012 به میزبانی می شود. بیماریهای عصبی مانند بیماری آلزایمر ، بیماری پارکینسون ، اسکلروز جانبی آمیوتروفیک (ALS) و زوال عقل Frontotemporal (FTD). شرکت کنندگان از آکادمی ؛ صنایع دارویی و بیوتکنولوژی ؛ سازمان های دولتی مانند انستیتوی ملی بهداشت و وزارت امور ایثارگران ایالات متحده (VA) ؛ گروه های وکالت بیمار ؛ و بنیادهای خصوصی فرصت های بالقوه برای همکاری در جوامع تحقیق و توسعه مربوطه را ارائه و شناسایی کردند. این گزارش مشترکات مربوط به مکانیسم های ژنتیکی و سلولی را شناسایی و مورد بحث قرار می دهد ، زمینه های علم اساسی مورد نیاز برای تسهیل توسعه درمانی را مشخص می کند و زمینه های همکاری بالقوه بین جوامع تحقیقاتی مربوطه را مورد بررسی قرار می دهد.