توضیحات
The importance of CK2 in cancer and other diseases has generated a significant amount of literature on the protein, and an international community of CK2 researchers. The International Union of Biochemistry and Molecular Biology (IUMBMB) sponsors periodic international conferences on CK2, making the protein a natural topic for a Wiley-IUBMB publication.
Protein Kinase CK2 will deal with structural aspects underlying the constitutive activity of CK2, its specific susceptibility to pharmacological inhibition and its extraordinary pleiotropy. In the second part the fundamental role of CK2 in a wide number of biological functions will be illustrated, while the third part will be devoted to the unusual mode of implication of CK2 in neoplastic transformation, with an appendix reviewing its potential relevance to other pathologies.
Content:
Chapter 1 Structural Bases of Protein Kinase CK2 Function and Inhibition (pages 175): Karsten Niefind and Roberto Battistutta
Chapter 2 The Interactome of Protein Kinase CK2 (pages 76116): Mathias Montenarh and Claudia Gotz
Chapter 3 CK2 Contribution to the Generation of the Human Phosphoproteome (pages 117128): Luca Cesaro and Mauro Salvi
Chapter 4 CK2 in Embryonic Development (pages 129168): Laura Macias Alvarez, Jesus Revuelta?Cervantes and Isabel Dominguez
Chapter 5 Protein Kinase CK2: At the Crossroads of Pathways Controlling Cell Proliferation and Survival (pages 169189): Michelle Gabriel and David W. Litchfield
Chapter 6 The Role of Protein Kinase CK2 in the p53 Response (pages 190204): David W. Meek
Chapter 7 The Pivotal Role of CK2 in the Kinome?Targeting Hsp90 Chaperone Machinery (pages 205238): Yoshihiko Miyata
Chapter 8 CK2: A Global Regulator of Cell Survival (pages 239266): Barbara Guerra and Olaf?Georg Issinger
Chapter 9 Specific Features of Plant CK2 (pages 267289): Marta Riera, Isabel Cristina Velez?Bermudez, Tommaso Legnaioli and Montserrat Pages
Chapter 10 The Oncogenic Potential of CK2 (pages 292304): David C. Seldin and Esther Landesman?Bollag
Chapter 11 Addiction of Cancer Cells to CK2: Survival at All Costs or Achilles’ Heel? (pages 305318): Maria Ruzzene
Chapter 12 CK2 Suppression of Apoptosis and Its Implication in Cancer Biology and Therapy (pages 319343): Janeen H. Trembley, JingJiang Wu, Gretchen M. Unger, Betsy T. Kren and Khalil Ahmed
Chapter 13 Protein Kinase CK2 in Normal and Malignant Hematopoiesis (pages 344362): Francesco Piazza
Chapter 14 Role of CK2 in the Control of Cell Plasticity in Breast Carcinoma Progression (pages 363382): Odile Filhol, Alexandre Deshiere and Claude Cochet
Chapter 15 CK2 as a Logical Target in Cancer Therapy: Potential for Combining CK2 Inhibitors with Various Classes of Cancer Therapeutic Agents (pages 383439): Denis Drygin
Chapter a01 Appendix: CK2 and Its False Sisters: The Recent Solution of a Very Cold Case (pages 440441):
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ترجمه ماشینی :
اهمیت CK2 در سرطان و سایر بیماری ها، حجم قابل توجهی از ادبیات را در مورد پروتئین و جامعه بین المللی محققان CK2 ایجاد کرده است. اتحادیه بینالمللی بیوشیمی و زیستشناسی مولکولی (IUMBMB) از کنفرانسهای بینالمللی دورهای در مورد CK2 حمایت میکند و پروتئین را به موضوعی طبیعی برای انتشارات Wiley-IUBMB تبدیل میکند.
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